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Probiotics

Is your intestinal bacteria normal ? -
(or been wiped out by medications and unhealthy eating?

An Introduction to Probiotics –
National Center for Complimentary and Alternative Medicine

http://nccam.nih.gov/health/probiotics/

Introduction
Probiotics are live microorganisms (in most cases, bacteria) that are similar to beneficial microorganisms found in the human gut. They are also called "friendly bacteria" or "good bacteria." Probiotics are available to consumers mainly in the form of dietary supplements
and foods. They can be used as complementary and alternative medicine (CAM).

Key Points
•    People use probiotic products as CAM to prevent and treat certain illnesses and
support general wellness.
•    There is limited evidence supporting some uses of probiotics. Much more scientific
        knowledge is needed about probiotics, including about their safety and appropriate use.
•    Effects found from one species or strain of probiotics do not necessarily hold true
        for others, or even for different preparations of the same species or strain.

What Probiotics Are
Experts have debated how to define probiotics. One widely used definition, developed by the World Health Organization and the Food and Agriculture Organization of the United Nations,
is that probiotics are "live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host." (Microorganisms are tiny living organisms—
such as bacteria, viruses, and yeasts—that can be seen only under a microscope.)

Probiotics are not the same thing as prebiotics—nondigestible food ingredients that selectively stimulate the growth and/or activity of beneficial microorganisms already
in people's colons. When probiotics and prebiotics are mixed together, they form a synbiotic.

Probiotics are available in foods and dietary supplements (for example, capsules, tablets,
and powders) and in some other forms as well. Examples of foods containing probiotics are yogurt, fermented and unfermented milk, miso, tempeh, and some juices and soy beverages. In probiotic foods and supplements, the bacteria may have been present originally or added during preparation.

Most probiotics are bacteria similar to those naturally found in people's guts, especially
in those of breastfed infants (who have natural protection against many diseases).
Most often, the bacteria come from two groups, Lactobacillus or Bifidobacterium.
Within each group, there are different species (for example, Lactobacillus acidophilus and Bifidobacterium bifidus), and within each species, different strains (or varieties).
A few common probiotics, such as Saccharomyces boulardii, are yeasts, which are different from bacteria.

Some probiotic foods date back to ancient times, such as fermented foods and cultured milk products. Interest in probiotics in general has been growing; Americans' spending on
probiotic supplements, for example, nearly tripled from 1994 to 2003.

Uses for Health Purposes
There are several reasons that people are interested in probiotics for health purposes.

First, the world is full of microorganisms (including bacteria), and so are people's bodies—
in and on the skin, in the gut, and in other orifices. Friendly bacteria are vital to proper development of the immune system, to protection against microorganisms that could
cause disease, and to the digestion and absorption of food and nutrients.
Each person's mix of bacteria varies. Interactions between a person and
the microorganisms in his body, and among the microorganisms themselves,
can be crucial to the person's health and well-being.

This bacterial "balancing act" can be thrown off in two major ways:

1.    By antibiotics, when they kill friendly bacteria in the gut along with unfriendly bacteria. Some people use probiotics to try to offset side effects from antibiotics like gas, cramping,
or diarrhea. Similarly, some use them to ease symptoms of lactose intolerance—
a condition in which the gut lacks the enzyme needed to digest significant amounts
of the major sugar in milk, and which also causes gastrointestinal symptoms.

2.    "Unfriendly" microorganisms such as disease-causing bacteria, yeasts, fungi, and
parasites can also upset the balance. Researchers are exploring whether probiotics could
halt these unfriendly agents in the first place and/or suppress their growth and activity
in conditions like:

•    Infectious diarrhea
•    Irritable bowel syndrome
•    Inflammatory bowel disease (e.g., ulcerative colitis and Crohn's disease)
•    Infection with Helicobacter pylori (H. pylori), a bacterium that causes most ulcers
      and many types of chronic stomach inflammation
•    Tooth decay and periodontal disease
•    Vaginal infections
•    Stomach and respiratory infections that children acquire in daycare
•    Skin infections

Another part of the interest in probiotics stems from the fact there are cells in the digestive tract connected with the immune system. One theory is that if you alter the microorganisms
in a person's intestinal tract (as by introducing probiotic bacteria), you can affect the
immune system's defenses.

What the Science Says
Scientific understanding of probiotics and their potential for preventing and treating health conditions is at an early stage, but moving ahead. In November 2005, a conference that
was cofunded by the National Center for Complementary and Alternative Medicine (NCCAM) and convened by the American Society for Microbiology explored this topic.

According to the conference report, some uses of probiotics for which there is some encouraging evidence from the study of specific probiotic formulations are as follows:

•    To treat diarrhea (this is the strongest area of evidence, especially for diarrhea from
        rotavirus)
•    To prevent and treat infections of the urinary tract or female genital tract
•    To treat irritable bowel syndrome
•    To reduce recurrence of bladder cancer
•    To shorten how long an intestinal infection lasts that is caused by a bacterium called
         Clostridium difficile
•    To prevent and treat pouchitis (a condition that can follow surgery to remove the colon)
•    To prevent and manage atopic dermatitis (eczema) in children

The conference panel also noted that in studies of probiotics as cures, any beneficial effect
was usually low; a strong placebo effect often occurs; and more research (especially in the form of large, carefully designed clinical trials) is needed in order to draw firmer conclusions.

Some other areas of interest to researchers on probiotics are

•    What is going on at the molecular level with the bacteria themselves and how
        they may interact with the body (such as the gut and its bacteria) to prevent and
        treat diseases. Advances in technology and medicine are making it possible
        to study these areas much better than in the past.
•    Issues of quality. For example, what happens when probiotic bacteria are treated or
       are added to foods—is their ability to survive, grow, and have a therapeutic effect altered?
•    The best ways to administer probiotics for therapeutic purposes, as well as the best
        doses and schedules.
•    Probiotics' potential to help with the problem of antibiotic-resistant bacteria in the gut.
•    Whether they can prevent unfriendly bacteria from getting through the skin or mucous
        membranes and traveling through the body (e.g., which can happen with burns,
        shock, trauma, or suppressed immunity).

Side Effects and Risks
Some live microorganisms have a long history of use as probiotics without causing illness
in people. Probiotics' safety has not been thoroughly studied scientifically, however.
More information is especially needed on how safe they are for young children, elderly people, and people with compromised immune systems.

Probiotics' side effects, if they occur, tend to be mild and digestive (such as gas or bloating). More serious effects have been seen in some people. Probiotics might theoretically cause infections that need to be treated with antibiotics, especially in people with underlying health conditions. They could also cause unhealthy metabolic activities, too much stimulation of the immune system, or gene transfer (insertion of genetic material into a cell).

Probiotic products taken by mouth as a dietary supplement are manufactured and
regulated as foods, not drugs.

Some Other Points To Consider
•    If you are thinking about using a probiotic product as CAM, consult your health care
        provider first. No CAM therapy should be used in place of conventional medical care
        or to delay seeking that care.
•    Effects from one species or strain of probiotics do not necessarily hold true for others,
       or even for different preparations of the same species or strain.
•    If you use a probiotic product and experience an effect that concerns you,
        contact your health care provider.
•    You can locate research reports in peer-reviewed journals on probiotics' effectiveness
         and safety through the resources PubMed and CAM on PubMed®.

NCCAM-Sponsored Research on Probiotics
Among recent NCCAM-sponsored research are the following projects:

•    Investigators at Tulane University School of Public Health and Tropical Medicine are studying the effectiveness of selected probiotic agents to treat diarrhea in undernourished children in a developing country.

•    At the Mayo Clinic College of Medicine, researchers have been examining probiotics for possibly decreasing the levels of certain substances in the urine that can cause problems
such as kidney stones.

•    A team at Tufts-New England Medical Center is studying probiotics for treating an antibiotic-resistant type of bacteria that causes severe infections in people who are hospitalized, live in nursing homes, or have weakened immune systems.

References :
Sources are primarily recent reviews on the general topic of probiotics in the peer-reviewed medical and scientific literature in English in the PubMed database, selected evidence-based databases, and Federal Government sources.

1994–2004 U.S. specialty/other supplement sales. Nutrition Business Journal. 2005.
Accessed on December 7, 2006.

Alvarez-Olmos MI, Oberhelman RA. Probiotic agents and infectious diseases: a modern perspective on a traditional therapy. Clinical Infectious Diseases. 2001;32(11):1567–1576.

Bifidobacteria. Natural Medicines Comprehensive Database Web site. Accessed on
December 7, 2006.

Bifidus. Thomson MICROMEDEX AltMedDex System. Web site Accessed on December 7, 2006.

Cabana MD, Shane AL, Chao C, et al. Probiotics in primary care pediatrics. Clinical Pediatrics. 2006;45(5):405–410.

Doron S, Gorbach SL. Probiotics: their role in the treatment and prevention of disease.
Expert Review of Anti-Infective Therapy. 2006;4(2):261–275.

Ezendam J, van Loveren H. Probiotics: immunomodulation and evaluation of safety and efficacy. Nutrition Reviews. 2006;64(1):1–14.

Food and Agriculture Organization (FAO) of the United Nations and World Health Organization (WHO). Guidelines for the Evaluation of Probiotics in Food. Report of a Joint FAO/WHO
Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food.
Accessed on December 7, 2006.

Gill HS, Guarner F. Probiotics and human health: a clinical perspective. Postgraduate Medical Journal. 2004;80(947):516–526.

Hammerman C, Bin-Nun A, Kaplan M. Safety of probiotics: comparison of two popular strains.
BMJ. 2006;333(7576):1006–1008.

Huebner ES, Surawicz CM. Probiotics in the prevention and treatment of gastrointestinal infections. Gastroenterology Clinics of North America. 2006;35(2):355–365.

Lactobacillus. Natural Medicines Comprehensive Database Web site. Accessed on
December 7, 2006.

Lactobacillus. Thomson MICROMEDEX AltMedDex System Web site. Accessed on
December 7, 2006.

Probiotics: Bottom Line Monograph. Natural Standard Database Web site. Accessed on December 7, 2006.

Reid G, Hammond JA. Probiotics: some evidence of their effectiveness. Canadian Family Physician. 2005;51:1487–1493.

Salminen SJ, Gueimonde M, Isolauri E. Probiotics that modify disease risk.
Journal of Nutrition. 2005;135(5):1294–1298.

Vanderhoof JA, Young RJ. Current and potential uses of probiotics. Annals of Allergy,
Asthma, & Immunology. 2004; 93(5 suppl 3):S33–S37.

Walker R, Buckley M. Probiotic Microbes: The Scientific Basis. Report of an American Society
for Microbiology colloquium; November 5–7, 2005; Baltimore, Maryland. American Society
for Microbiology Web site. Accessed on December 7, 2006.

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